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Next-generation biotherapy
monitoring

The right dose
for each patient

mAbXmise determines the plasma concentration of therapeutic mAbs prescribed as single or combination therapies at selected time points. The kit is designed to be easy-to-handle and allows optimal reliability and accuracy using mass spectrometry technology. Healthcare professionals can then use the information to personalize each mAb therapy.

Therapeutic Drug Monitoring

Therapeutic drug monitoring consists of measuring the plasma concentration of a drug, so as to adjust the dosing and maintain its target plasma concentration.

Since the 2000s, monitoring of therapeutic antibodies has begun to emerge in the management of inflammatory diseases and oncology, with immunological methods.

mAbXmise uses a different approach. It lies on mass spectrometry, a particularly sensitive and above all extremely specific technology. The technology allows the therapeutic antibody in the sample to be measured very accurately.

We believe the onset of mAbXmise technology will dramatically change the way biologics are monitored in the future.

Current treatment regimens are still either single-dose or calculated on the basis of patient weight, whereas there is increasing evidence of inter-patient variability due to several factors such as age, gender, pathological state and others.

With mAbXmise, we hope we can facilitate the adoption of this practice in the hospital, to allow individualized medicine and compensate for inter-individual variability.

We believe our diagnostics kits will enable the medical team to better manage treatment efficacy and side-effects.

 

Our range of
diagnostic kits

The range developed by Promise Proteomics includes two products:

  • a kit specifically designed for monitoring therapeutic antibodies prescribed for inflammatory diseases and
  • a second kit, targeting antibodies prescribed for the treatment of cancers.

Our PRODUCTS

INFLAMMATION

1 KIT for 2 mAbs

Infliximab

Adalimumab

ONCOLOGY

1 KIT for 7 mAbs

Bevacizumab

Rituximab

Cetuximab

Trastuzumab

Nivolumab

Pembrolizumab Ipilimumab

INCLUDED IN EACH KIT :

-96 well plate coated with stable labelled mAbs (internal standards)

-6 Calibrators

-2 Quality Controls

-Suited buffers and solutions

-Specific consumables

-Protease

Our technology step-by-step

Key assets

From the patient’s blood sample to the monitoring of therapeutic antibodies,
mAbXmise diagnostic kits are:

EASY-TO-USE

sample preparation

with mAbXmise labelled

internal standards added

to blood sample

MULTIPLEX

quantitative analysis

using mass spectrometry,

measuring simultaneously

several therapeutic mAbs

ACCURATE

measurement of therapeutic mabs

with 100% accuracy and

specificity according to

the peptide signature

Our company

Promise Proteomics was created in 2010 as a spin-off of CEA Grenoble (France). This medtech company is currently wholly owned by the Aguettant group and is directed by Dr Eric Rougemond.

 

Since 2013, Chief Scientific Officer of Promise, Dorothee Lebert, has led ambitious and collaborative R&D programs which have allowed to develop the technology, on which the diagnostic kits for personalized medical applications are based.

 

Capitalizing on its unique know-how in the production of internal standards for protein assays and its recognized expertise in mass spectrometry-based quantification methods, Promise Proteomics is placing its skills at the service of healthcare professionals through its mAbXmise kits.

Our team

Promise proteomics’ team is led by Dr Eric Rougemond, CEO and Dorothée Lebert, CSO and gathers the right expertises to implement successfully TDM solutions.

 

3

patents

3

patents

7

articles on Therapeutic
Drug Monitoring

7

articles on Therapeutic
Drug Monitoring

10

years of expertise
in proteomics

10

years of expertise
in proteomics

6

collaborations in
Europe and US

6

collaborations in
Europe and US

Our references & awards

 

KEY REFERENCES

> Determination of Cetuximab in Plasma by Liquid Chromatography-High-Resolution Mass Spectrometry Orbitrap With a Stable Labeled 13C,15N-Cetuximab Internal Standard.

Ther Drug Monit. 2019

 

> Infliximab quantitation in human plasma by liquid chromatography-tandem mass spectrometry: towards a standardization of the methods?

Analytical and Bioanalytical Chemistry, 2017

AWARDS

> Awardee of the Proof-of-concept program for ambitious R&D programs in public-private partnership, addressing a medical need in Oncology (2017)

 

> Semifinalist of AACC’s disruptive technology award session rewarding the next innovative testing solution that will transform patient care (2018)

 

 

Pilot clinical study at Lyon University Hospital (HCL, France)

Launched in 2017, MADMAS study aims at developing a dosing method to monitor plasma levels of nivolumab, pembrolizumab and ipilimumab and to draw a exposure-response correlation in patients with lung cancer and melanoma.

Quality Affairs & Regulatory affairs

Promise Proteomics is currently filling the technical dossier for the CE marking for the European market
and will then seek approval by the Food and Drug Administration (FDA 510K) for the US market.
ISO9001 and ISO13485 quality certifications are also equally underway.