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Gathering analytical, pharmacological and clinical expertise with one objective: to completely transform the patient journey.
Now available in clinical practice, mAbXmise kits are designed to help healthcare professionals in their decision making when crafting effective treatment plans. Our kits can help provide unique-to-patient information in many therapeutic areas, allowing accurate dosage adjustment and a reduction in treatment costs.
An invaluable tool for hospital pharmacists using TDM, mAbXmise provides accurate insights which can then be applied to patient treatment plans. mAbXmise kits offer a more sustainable alternative to generic prescriptions: Often the results of TDM leads to a reduction in drug dosage, proving cost effectiveness and helping patient well-being[1].
mAbXmise determines the plasma concentration of monoclonal antibodies prescribed as single or combination therapies at selected time points. Its unique technology is based on mass spectrometry and allows multiplex measurement (several mAbs at once) with high analytical performances. The kit is designed to be easy to use and allows optimal reliability and accuracy using LC/MS technology[1].
Promise Proteomics is dedicated to bringing transforming solutions that will make personal, individualized therapy a reality for patients. Ultimately this will improve the patient experience, and patients’ prognoses.
“A few years ago, I would say that LC/MS is not suitable for mAbs because LC/MS is more suitable in measuring small molecules and it’s very complicated to measure proteins and mAbs. Today, the method is more reliable and can be successfully used with generic kits. With the kits, it’s easier to implement them in clinical practice. The instructions are very clear.”
Pharmacologist, The Netherlands
Drug monitoring helps reduce the chance of toxicity: Overexposure can be anticipated by monitoring drug concentration in blood[2]
This multiplex LC-MS/MS method outperforms other methods for patient receiving combination therapies (or treated conjointly with 2 monoclonal antibodies), saving time and money[3]
Mass spectrometry produces an analytical robustness compared to immunoassays[4]
Our mAbXmise kits are complete read-to-use solutions for facilitating the quantification of monoclonal antibodies using mass spectrometry in the laboratory.
SIL-mAbs are incorporated in our mAbXmise kits for ensuring quantification performances.
The solution provided enables to perform the pre-analytical steps before LC-MS analysis, and is compatible with most of the LC-MS configurations and brands.
To ensure a satisfaying experience, technical support is provided and our application team wil be at your side during the implementation phase.
INCLUDED IN EACH KIT :
-96 well plate coated with stable labelled mAbs (internal standards)
-6 Calibrators
-2 Quality Controls
-Suited buffers and solutions
-Specific consumables
-Protease
3 kits are CE-IVDD*, 4 kits are CE-IVDR** and 4 kits are still in the pipeline to obtain CE-IVDR marking. Meanwhile, they can be already used as Research Use Only products.
sample preparation with mAbXmise labelled
internal standards added to blood sample
quantitative analysis
using mass spectrometry,
measuring simultaneously
several therapeutic mAbs
measurement of therapeutic mAbs
with 100% accuracy and
specificity according to
the peptide signature
“Current treatment regimens are still either single-dose or calculated on the basis of patient weight, whereas there is increasing evidence of inter-patient variability due to several factors such as age, gender, pathological state and others.
With mAbXmise, we hope we can facilitate the adoption of this practice in the hospital, to allow individualized medicine by personalizing the frequency of administration, compensate for inter-individual variability and reducing treatment costs.”[3]
Dorothée LEBERT, Chief Scientific Officer, Promise Proteomics
mAbXmise monoclonal antibodies quantification kits are In Vitro Diagnostic Medical Devices for laboratory professional use and CE-IVD labeled for Europe by BSI. Assay results are intended to be used by healthcare professionals. The kits are designed to perform absolute quantification by LC-MS (Liquid Chromatography – Mass spectrometry) of specific therapeutic monoclonal antibodies (mAbs) in a patient sample. Assay results are intended to be used by healthcare professionals. Before use, it is important to carefully read the instructions provided with the product. The products are non-refundable. The mAbXmise Kit described has not been cleared by any regulatory entity for diagnostic purposes outside of Europe. Proteomics mAbXmise Kits are not available for sale in all countries.
Promise Proteomics was created in 2010 as a spin-off of CEA Grenoble (France). This medtech company is currently wholly owned by the Aguettant group and is directed by Dr Eric Rougemond.
Since 2013, Chief Scientific Officer of Promise, Dorothee Lebert, has led ambitious and collaborative R&D programs which have allowed to develop the technology, on which the diagnostic kits for personalized medical applications are based.
Capitalizing on its unique know-how in the production of internal standards for protein assays and its recognized expertise in mass spectrometry-based quantification methods, Promise Proteomics is placing its skills at the service of healthcare professionals through its mAbXmise kits.
Importantly, we are an integrated research & diagnostics company, meaning that we have the capabilities and experience to manage innovation, development or research & IVD products, manufacturing and market access.
Currently, the company holds 2 ISO certifications: ISO9001 and ISO13485, its QMS is CE-IVDR certified.
mAbXmise range counts already 3 CE-IVDD and 4 CE-IVDR products.
Lean more about Promise Proteomics
clinical articles published citing mAbXmise kits
clinical articles published citing mAbXmise kits
clinical reseach studies ongoing in Europe using our kits
clinical reseach studies ongoing in Europe using our kits
patents
patents
multiplex kits
available
multiplex kits
available
mAbs available in our solutions (kits and SIL-mAbs)
mAbs available in our solutions (kits and SIL-mAbs)
therapeutic areas
therapeutic areas
KEY REFERENCESDiscover our references in our Resource Library |
AWARDS>Awardee of the Proof-of-concept program for ambitious R&D programs in public-private partnership, addressing a medical need in Oncology (2017)> Semifinalist of AACC’s disruptive technology award session rewarding the next innovative testing solution that will transform patient care (2018) |
The related patents numbers are :US11543416, US11053303, US11630111, EP3165928, EP3165922, EP3457139 and EP4231017 |
[1] Puszkiel, A.; et al. Extending the dosing intervals of nivolumab: model-based simulations in unselected cancer patients. (2024). British Journal Of Cancer, 130(11), 1866‑1874. https://doi.org/10.1038/s41416-024-02659-x
[2] Broué, F. Advantages of monitoring biotherapies in oncology. La Lettre du Cancérologue, 90-91. 2022
[3] Marin, C.; et al. Cross-Validation of a Multiplex LC-MS/MS Method for Assaying mAbs Plasma Levels in Patients with Cancer: A GPCO-UNICANCER
Study. Pharmaceuticals 2021, 14, 796. https://doi.org/10.3390/ph14080796
[4] Millet A, Khoudour N, Guitton J, Lebert D, Goldwasser F, Blanchet B, Machon C. Analysis of Pembrolizumab in Human Plasma by LCMS/HRMS. Method Validation and Comparison with Elisa. Biomedicines. 2021 May 30
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Promise Proteomics
7, parvis Louis Néel • BHT 52 A • CS 20050
38040 Grenoble Cedex 9 • FRANCE
PHONE: +33 4 38 02 36 50
Last update: September, 2024 – Internal code: PROM-0023.V01-09.24
